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I don't see any way to implement this.

XenDesktop would have been the closest thing I can think of, but it's been discontinued years ago, and it involved VMs, which you don't want. It mapped hardware directly through though and allowed to use single applications from VM A directly inside VM B, which made it pretty interesting.

I remember seeing machines which basically were two computers in the same case, but that were servers and it was for implementing redundancy. Not really an option for end users either.